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Contribution of mechanical forces in multiciliated cell differentiation

Nathalie Delgehyr, Nathalie Spassky

doi:10.1098/rsob.260101

Abstract

Multiciliated cells, through the coordinated beating of motile cilia, are vital for moving fluids in the brain and mucus in the airways and in the reproductive organs. Their dysfunction leads to diseases, associated with chronic airway infections, subfertility and ventricular enlargement. A group of transcription factors and a cell cycle variant enable the differentiation of multiciliated cells. However, how the multiciliated differentiation programme is initiated, timed and spatially regulated within developing tissues remains unclear. In this review, we combine findings from airway, brain ventricles and Xenopus epidermal systems to reveal how mechanical cues may interact with transcriptional networks and cell cycle regulators during multiciliogenesis. We suggest a model where mechanical forces serve as contextual regulators that enable, time and control the execution of the multiciliated differentiation programme.

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Ratings

Contribution of mechanical forces in multiciliated cell differentiation scores 91/100 for reproducibility readiness on LabsTrail. How the score works

Reproducibility readiness

How completely the paper reports what others need to repeat its work, from 0 to 100, checked against the reporting checklist for each kind of study in it. It doesn't say whether the findings are right.

91/ 100

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History

  1. 20 Oct 2026Scored 91Details
  1. Reproducibility readinesslive
  2. Human reviewnext
  3. Wet-lab replicationlater